TRF (tissue regeneration factors) 150- 30 caps

Wow! A supplement that can actually help the body regrow normal bone and cartilage (and even other connective tissues). Thousands of research studies. Use of this product in my own arthritic dog has markedly improved his quality of life.

What is TRF 150™?

TRF 150™ (Tissue Regeneration Factor) features 150 mg of Cyplexinol™, a bone-derived protein/collagen complex containing Bone Morphogenetic Proteins (BMPs) and key growth factors naturally contained in bone, such as Transforming Growth Factor Beta (TGF-?), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor (PDGF), and Basic Fibroblast Growth Factor (bFGF).

Applications of TRF 150™ in Pets

(though this supplement is marketed for people)
Clinical effects of the results of supplemental BMPs are validated with multiple studies.  TRF 150™ is effective in helping to maintain bone strength and joint homeostasis, as well as the pathways which cause cartilage degradation because it features thoroughly researched Cyplexinol™. The proteins (found in bone and bovine milk) contained in Cyplexinol™ have been shown to activate the bone and cartilage-forming process. TRF’s Cyplexinol™ exerts its effect on bone via increasing bone formation and reducing bone resorption.

This allows TRF 150™ to address the processes which lead to cartilage degradation, as well as the ensuing pain and inflammation caused by arthritis and other degenerative joint conditions.   TRF 150™ should be a first line defense for any stage of osteoporosis, any type of fracture and for any condition in need of joint or cartilage repair.  Consider pairing it with other joint supplements.

Cyplexinol™ studies conclude:
Cyplexinol is a bone anabolic agent  (tissue regenerating)
Bone volume of rats increased by 78% given Cyplexinol
Promotes bone formation  and reduces bone resorption
Improves bone mineral density even in ovariectomized rats
Improves bone mass caused by estrogen decline
Improves trabecular bone architecture,  trabecular thickness,  and trabecular connectivity
Important morphogens with pleiotropic functions

Mechanisms of action of Tissue Regeneration Factor:

Bone and Cartilage: Osteoinductive effect (stimulating new bone formation)
Bone Morphogenetic Proteins stimulate mesenchymal stem cells and differentiate them into osteoblasts (produce bone) and chondrocytes (produce cartilage).

Arthritis (rheumatoid and osteo):   Anti-inflammatory effect
Bone Morphogenetic Proteins have an antagonistic effect towards key pro-inflammatory cytokines (such as IL-1 and IL-6) and transcription factors all which are responsible for inflammation. BMPs have been studied for both rheumatoid and osteoarthritis (these patients are low in BMPs).

TRF 150’s Cyplexinol™ is also involved in the maintenance and repair of articular cartilage, which covers the surface of a joint where the ends of bones meet. When this cartilage becomes damaged, the bones will grind against each other instead of having a smooth, fluid movement. Since there is no direct blood supply to cartilage, damage to these areas from injuries, misuse, or overuse leads to pain and inflammation with potentially extended recovery time.
In summary, this product is ideal for healing broken bones, osteoporosis, cartilage repair, arthritis and other degenerative joint conditions.

*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.